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eases), Society for Experimental Riolog>- and Medicine, Medico-Legal Society, Northwestern Medical and Surgical Society of New York, the Women's Medical .Association of New York City (annual). Alumni Association of City Hospital (annual) ; Thursday. May i6th, the New York Celtic Medical Society, New York Academy of Medicine (stated meetings) ; Friday, May 17th. New York .Academy of Medicine (Section in Orthopedic Surgery), Clinical So- ciety of the New York Postgraduate Medical School and Hospital, New York Microscopical Society, Brooklyn Medi- cal Society. Personal. — Dr. .Abraham Jacobi celebrated his eighty- eighth birthday on May 6th, and was the recipient Cialis Generico Farmacia Europea of con- gratulations from manyilhistrious members of the medical profession. -Assistant Surgeon Thomas F. Keating, United States Public Health Service, has resigned from the service, resig- nation to be effective June 3, 1918. Dr. Joseph Engel, of 102 South Ninth Street, Brookl>-n. has been appointed assistant radiographer to Bcllevuc Hos- pital. Dr. J. G. .Adami. of Cialis Generico Farmacia Europea Montreal, Colonel. Canadian Army Medical Corps, has completed the first volume of his his- tory of the corps. It will be published shortly. Lieutenant Peter K. Olitsky. Medical Reserve Corps, U. S. .'\rmy, a member of the Cialis Generico Farmacia Europea staff of the Rockefeller In- stitute for Medical Rejiearch, has been granted permission by the Surgeon Cicneral to go to Hong Kong to assist in controlling a local outbreak of meningitis. Doctor Olitsky will advise the Hong Kong government concerning the control of the disesae, and especially in the preparation of an effective Cialis Generico Farmacia Europea serum and the institution of other therapeutic .•\nd prophylactic measures. Dr. .\llan J. McUaugblin. who was granted leave of ab- sence by the United States PiiM'^- Tle.iMi Srr\|,r to l.ocome , health commissioner of Mas- ' ' to the service. He has been 1 .;en- eral and placed in charge ■ -tate Quarantine. Dr. Eugene R. KcUc;,. ul;-i :■.■: V.:c past three years has been director of the department of communicable diseases of the Massachusetts Department of He.ilth. has been appointed health commissioner, to succeed Doctor McLaughlin. Modern Treatment and Preventive Medicine A Compendium of Therapeutics and Prophylaxis, Original and Adapted THE TREATMENT OF HEMOPHILIA. By Louis T. de M. Sajous, B. S., M. D., Philadelphia. {^Concluded from page 8^4.) Organ extracts have been employed in hemophilia chiefly for local hemostatic purposes, presumably supplying a thromboplastic substance which in the hemophilic is not set tree with sufficient rapidity at the site of bleeding to permit of prompt coagulation. At least one of the extracts of the ductless glands, however, appears to yield definite results when given by mouth. Dejace in 1897 'ind Combemale in 1898 seem to have been the first to apply thyroid treatment in excessive bleedings, but their cases were instances of purpura and not of familial hemophilia. R. Jones, 1900, and E. Fuller, 1903, reported — describing them as hemophilics — cases in which prompt benefit from thyroid treatment had been obtained. More conclu- sive, perhaps, as regards the value of thyroid pro- ducts in true hemophilia — although Hess, 1916, maintains that purpura is sometimes hereditary — is a case reported by W. J. Taylor, 1905, in which, at the suggestion of C. E. de M. Sajous, thyroid substance was given to a boy 18 years old, member of a family of bleeders, who bled for weeks from the site of an operation for necrosis of the fibula following osteo- myelitis. Various remedies had been tried in turn without result, but upon instituting thyroid medica- tion a marked change for the b.etter was seen almost immediately. After a week of this treatment all bleeding from the granulations ceased and the wound liegan to heal rapidly. In another case reported by Taylor, in which profuse bleeding had always fol- lowed even the simplest wounds — and purpuric spots at one time been noted — the coagulation time was re- duced by thyroid substance, in doses of three grains three times a day, from eleven and one half minutes to two minutes and six seconds, and a nephropexy was performed without difficulty from hemorrhage, the wound in fact being "remarkably dry." In a tiiird case, that of a woman who had been Cialis Generico Farmacia Europea a bleeder all her life and bled forty-eight hours after extrac- tion of a tooth, thyroid substance was given for pro- phylactic purposes for two days before extraction of two other teeth. In spite of unusual trauma during the extraction, bleeding was less than occurs in the average normal subject. Experiences such as the above would seem to ren- der a trial of thyroid medication very advisable in the entire group of "bleeders." Over serum or blood treatment this measure obviously has the ad- vantage of greater ease of application. According to C. E. de M. Sajous, thyroid acts in these cases by stimulating the adrenals to an increased produc- tion of adrenoxidase, — a ferment not only sustain- ing general tissue respiration but also taking part in coagulation, and of which the blood platelets are constituted. The use of ovarian extract internallv in hemo- philia was suggested in 1904 by Lachlan Grant, who employed it Cialis Generico Farmacia Europea with the thought that the endocrine ovarian function in the Cialis Generico Farmacia Europea female might be the factor which prevents actual manifestations of the disease in this sex among hemophilic families. His Cialis Generico Farmacia Europea first successful case was in a boy, of known hemophilic tendency, with hemorrhage from a cut foot contin- uing in spite of all local treatment. The second case, reported in 1906, was that of an adult hemo- Cialis Generico Farmacia Europea philic Cialis Generico Farmacia Europea with joint hemorrhages and flushings of the face Cialis Generico Farmacia Europea and ears. Benefit followed the use of an ova- rian extract in doses of two to five grains three or four times a day. While several other observers have likewise used ovarian extract in hemophilia, the results, on the whole, Cialis Generico Farmacia Europea do not seem to have been