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Tliese latter go through the process called spore formation ; in Cialis Mg 20 liquid media they develop motility due to a single terminal flagellum. A "filter passer." — As in all cultures of the organ- ism there are some minute Cialis Mg 20 individuals, the fact that it is uniformly a filter passer is easily reconciled with the development of the rather large bacilh which cultures may be caused to produce. Thus it is evident that filter passing alone is no proof that the cause of any disease is too minute to be easily seen by the ordinary bacteriological microscope, nor even is it a good measure of the average size of Cialis Mg 20 the organism in question. One prominent bacteriologist, when it was first discovered that the infection of poliom.yelitis could pass the Berkefeld filter, declared that on this account all work which considered such an organism as a coccus or a bacillus the possible cause of the disease should be "cast aside," at the same time mentioning his own efforts as having "yielded results of an entirely different Cialis Mg 20 order." In the author's work, as published, it was shown that cultures in serum, in milk, or in bouillon could Cialis Mg 20 be passed through this filter. Temperature of groivth. — In various experiments the author found that the organism grew well at all temperatures between 'summer heat" (70° F.) and that of the body. This is of very great importance :n explaining the epidemiology of the malady. Resistance to pastcitrization. — In the work re- ferred to I stated that cultures could Cialis Mg 20 be readily grown in milk, and that Cialis Mg 20 such cultures survived the pasteurization process, i. e., heating to i42°-5° for one half hour. This Cialis Mg 20 is also very important in ex- plaining ways in which the disease becomes epi- demic. Animal experiments. — In a small percentage of cases I produced paralysis in experimental animals (bv intravenous inoculation) — rabbits, cats, dogs, and guineapigs— -with typical nerve centre lesions. ]n other instances dogs and cats, inoculated as mentioned, developed all the symptoms of distemper. A colt, being used to produce antipoliomyelitis serum, and subjected to intravenous inoculation with cultures of the bacillus, became suddenly ill and died with what would popularly be called "blind staggers." (Details of this interesting case are shortly to be published.) Symptoms of an abortive attack of poliomyelitis were produced in the experimenter through the ac- cidental inoculation of a culture into his eye. And mucus taken from his throat at this time produced paralysis in a rabbit (by direct intracerebral inocu- lation) and a contagious, fatal disease, with nerve centre lesions, among guineapigs, the first guineapig having been intraperitoneally injected with a bit of mucus from the same source. Serological tests. — Six cultures of poliomyelitis bacilli, from as many difl'erent sources, were tested for agglutination with blood from forty-four con- valescents and six acutely ill from poliomyelitis. Thirty-seven of the fifty blood specimens completely agglutinated, twenty-six m (i-io dilution; eleven in 1-40 dilution) one or more of the cultures, while thirteen specimens failed to agglutinate any one. All the specimens from the acute cases were among the latter. Aniipoiiomyelitis serum. — An antipoliomyelitis iiacillus serum was made in cats which agglutinated -Poliomyelitis bacillus, stnjit form. Magnification 1500. the culture used in eflecting its production in a di- lution of 1-600, while it only agglutinated four of the six cultures in dilutions of, respectively, 1-80, 1-40, 1-20, 1-10: it failed to agglutinate the remain- ing one of the six in the greatest strength tested May iS, ,918.] GREELEY: POLIOMYELITIS. (l-io). As Cialis Mg 20 this seriiiii was tested on a patient, apparently with good effect, an effort was made to develop a similar scrum in the horse. (Jne agglutin- ating in a dilution of 1-1,600 has been produced, and, at present, opportunities for clinical testing are awaited. Distemper bacillus compared. — The organism Cialis Mg 20 rec- ognized as causing distemi)er Cialis Mg 20 in cats and dogs, and sometimes called the bacillus bronchosepticus, varies similarly in its forms and manner of growth, as I found by testing a culture obtained from a sick dog. The specific antipolioniyelitis serum agglutinated it in a dilution as great as 1-40, while the control (normal animal's blood) required i-io or greater strength. Blood from eleven poliomyelitis convales- cents was tested with a culture of the distemper bacillus : two specimens agglutinated it in a strength Fio. 3. — Poliomycliti.i b.ml form. Mafiiiification 1500. of 1-40. one in i-jo, li\e Cialis Mg 20 in i-io, and three did not